Abstract

Viral infections have detrimental impacts on neurological functions, and even to cause severe neurological damage. Very recently, coronaviruses (CoV), especially severe acute respiratory syndrome CoV 2 (SARS-CoV-2), exhibit neurotropic properties and may also cause neurological diseases. It is reported that CoV can be found in the brain or cerebrospinal fluid. The pathobiology of these neuroinvasive viruses is still incompletely known, and it is therefore important to explore the impact of CoV infections on the nervous system. Here, we review the research into neurological complications in CoV infections and the possible mechanisms of damage to the nervous system.

Keywords

Nervous systemCoronavirusSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)Central nervous systemMedicineCerebrospinal fluidRespiratory system2019-20 coronavirus outbreakBetacoronavirusPeripheral nervous systemCoronaviridaeImmunologyGuillain-Barre syndromeVirologyDiseasePathologyInternal medicineInfectious disease (medical specialty)Outbreak

MeSH Terms

BetacoronavirusCOVID-19Consciousness DisordersCoronavirus 229EHumanCoronavirus InfectionsCoronavirus NL63HumanCoronavirus OC43HumanDysgeusiaEncephalitisEncephalitisViralGuillain-Barre SyndromeHumansMiddle East Respiratory Syndrome CoronavirusNervous System DiseasesNeurotoxicity SyndromesOlfaction DisordersPandemicsPneumoniaViralPolyneuropathiesSevere acute respiratory syndrome-related coronavirusSARS-CoV-2SeizuresSevere Acute Respiratory SyndromeStroke

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Publication Info

Year
2020
Type
review
Volume
87
Pages
18-22
Citations
2079
Access
Closed

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Cite This

Yeshun Wu, Xiaolin Xu, Zijun Chen et al. (2020). Nervous system involvement after infection with COVID-19 and other coronaviruses. Brain Behavior and Immunity , 87 , 18-22. https://doi.org/10.1016/j.bbi.2020.03.031

Identifiers

DOI
10.1016/j.bbi.2020.03.031
PMID
32240762
PMCID
PMC7146689

Data Quality

Data completeness: 90%