Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Makoto Kuro‐o; Yutaka Matsumura; Hiroki Aizawa; Hiroshi Kawaguchi; Tatsuo Suga; Toshihiro Utsugi; Yoshio Ohyama; Masahiko Kurabayashi; Tadashi Kaname; Eisuke Kume; Hitoshi Iwasaki; Akihiro Iida; Takako Shiraki-Iida; Satoshi Nishikawa; Ryozo Nagai; Yo-ichi Nabeshima

doi:10.1038/36285

Keywords

KlothoAgeingPhenotypeGeneBiologyGene productCell biologyMutationGene expressionGeneticsKidney

Affiliated Institutions

Related Publications

De Novo Crypt Formation and Juvenile Polyposis on BMP Inhibition in Mouse Intestine

Anna-Pavlina G. Haramis , Harry Begthel , Maaike van den Born +4 more

Little is known about the signaling mechanisms that determine the highly regular patterning of the intestinal epithelium into crypts and villi. With the use of mouse models, we ...

2004 Science 760 citations

Epigenome-Wide Scans Identify Differentially Methylated Regions for Age and Age-Related Phenotypes in a Healthy Ageing Population

Jordana T. Bell , Pei-Chien Tsai , Tsun-Po Yang +19 more

Age-related changes in DNA methylation have been implicated in cellular senescence and longevity, yet the causes and functional consequences of these variants remain unclear. To...

2012 PLoS Genetics 697 citations

Transient depletion of xDnmt1 leads to premature gene activation in Xenopus embryos

Irina Stancheva , Richard R. Meehan

In Xenopus laevis zygotic transcription begins at the midblastula transition (MBT). Prior to this the genome is organized into chromatin that facilitates rapid cycles of DNA rep...

2000 Genes & Development 187 citations

The osteopetrotic mutation toothless ( tl ) is a loss-of-function frameshift mutation in the rat Csf1 gene: Evidence of a crucial role for CSF-1 in osteoclastogenesis and endochondral ossification

Liesbeth Van Wesenbeeck , Paul R. Odgren , Carole A. MacKay +5 more

The toothless ( tl ) mutation in the rat is a naturally occurring, autosomal recessive mutation resulting in a profound deficiency of bone-resorbing osteoclasts and peritoneal m...

2002 Proceedings of the National Academy o... 123 citations

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

David Malkin , Frederick P. Li , Louise C. Strong +8 more

Familial cancer syndromes have helped to define the role of tumor suppressor genes in the development of cancer. The dominantly inherited Li-Fraumeni syndrome (LFS) is of partic...

1990 Science 3748 citations

Publication Info

Year: 1997
Type: article
Volume: 390
Issue: 6655
Pages: 45-51
Citations: 3734
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

3734

OpenAlex

Cite This

APA Style

                            
                                
                                    Makoto Kuro‐o, 
                                
                                    Yutaka Matsumura, 
                                
                                    Hiroki Aizawa
                                
                                et al.
                            
                            (1997). 
                            Mutation of the mouse klotho gene leads to a syndrome resembling ageing. 
                            Nature
                            , 390
                            (6655)
                            , 45-51.
                            https://doi.org/10.1038/36285
                        

Identifiers

DOI: 10.1038/36285

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Keywords

Affiliated Institutions

Related Publications

De Novo Crypt Formation and Juvenile Polyposis on BMP Inhibition in Mouse Intestine

Epigenome-Wide Scans Identify Differentially Methylated Regions for Age and Age-Related Phenotypes in a Healthy Ageing Population

Transient depletion of xDnmt1 leads to premature gene activation in <i>Xenopus</i> embryos

The osteopetrotic mutation <i>toothless</i> ( <i>tl</i> ) is a loss-of-function frameshift mutation in the rat <i>Csf1</i> gene: Evidence of a crucial role for CSF-1 in osteoclastogenesis and endochondral ossification

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

Publication Info

External Links

Social Impact

Citation Metrics

Cite This

Identifiers