Abstract

In a large cohort of apparently healthy men, the presence of a specific point mutation in the factor V gene was associated with an increased risk of venous thrombosis, particularly primary venous thrombosis. The presence of the mutation was not associated with an increased risk of myocardial infarction or stroke. This mutation appears to be the most common inherited factor thus far recognized that predisposes patients to venous thrombosis.

Keywords

MedicineVenous thrombosisPulmonary embolismInternal medicineThrombosisRisk factorCardiologyStroke (engine)Myocardial infarctionFactor VGastroenterology

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Publication Info

Year
1995
Type
article
Volume
332
Issue
14
Pages
912-917
Citations
1051
Access
Closed

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Paul M. Ridker, Charles H. Hennekens, Klaus Lindpaintner et al. (1995). Mutation in the Gene Coding for Coagulation Factor V and the Risk of Myocardial Infarction, Stroke, and Venous Thrombosis in Apparently Healthy Men. New England Journal of Medicine , 332 (14) , 912-917. https://doi.org/10.1056/nejm199504063321403

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DOI
10.1056/nejm199504063321403