Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster.

Abstract

We report here that a point mutation in the gene which encodes the heterochromatin-specific nonhistone chromosomal protein HP-1 in Drosophila melanogaster is associated with dominant suppression of position-effect variegation. The mutation, a G-to-A transition at the first nucleotide of the last intron, causes missplicing of the HP-1 mRNA. This suggests that heterochromatin-specific proteins play a central role in the gene suppression associated with heterochromatic position effects.

Keywords

Variegation (histology)HeterochromatinHeterochromatin protein 1Position effectDrosophila melanogasterBiologyGeneticsEuchromatinMutationPoint mutationGeneChromosome

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Publication Info

Year: 1990
Type: article
Volume: 87
Issue: 24
Pages: 9923-9927
Citations: 565
Access: Closed

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APA Style

                            
                                
                                    Joel C. Eissenberg, 
                                
                                    Tharappel C. James, 
                                
                                    Dawn Foster‐Hartnett
                                
                                et al.
                            
                            (1990). 
                            Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster.. 
                            Proceedings of the National Academy of Sciences
                            , 87
                            (24)
                            , 9923-9927.
                            https://doi.org/10.1073/pnas.87.24.9923
                        

Identifiers

DOI: 10.1073/pnas.87.24.9923