Abstract
INTRODUCTION . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . 201 S OURCES OF AP SITES . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . 202 Spontaneous DepurinationlDepyrimidination . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 202 Chemically Induced DepurinationlDepyrimidination . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . 203 DepurinationlDepyrimidination by DNA Glycosylases . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . 207 REPAIR OF AP SITES . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . 209 MUTAGENESIS BY AP SITES . . . .... . . . . . . . . .. . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 210 Misincorporation by DNA Polymerases in vitro . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . 210 Mutagenesis in E. coli... . . . . . . . . . ..... . . . . . . . . . 2 1 2 Mutagenesis in Animal Cells . . . .. . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 1 3 A P Sites a s Intermediates in Spontaneous Mutagenesis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 214 AP Sites as Intermediates in Chemical Mutagenesis. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 216 MOLECULAR MECHANISMS FOR MUTAGENESIS BY AP S ITES . . . . . . . . .. . . . . . . . . . 219
Keywords
AP siteBiologyMutagenesisGeneticsComputational biologyMolecular biologyDNADNA repairMutationGene
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Publication Info
- Year
- 1986
- Type
- review
- Volume
- 20
- Issue
- 1
- Pages
- 201-230
- Citations
- 890
- Access
- Closed
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Cite This
Lawrence A. Loeb,
Bradley D. Preston
(1986).
MUTAGENESIS BY APURINIC/APYRIMIDINIC SITES.
Annual Review of Genetics
, 20
(1)
, 201-230.
https://doi.org/10.1146/annurev.ge.20.120186.001221
Identifiers
- DOI
- 10.1146/annurev.ge.20.120186.001221