Multisystem Inflammatory Syndrome in Children due to COVID-19, Causing Giant Coronary Artery Aneurysms

Abstract

According to the Centers for Disease Control (CDC) health advisory may 2020, Multisystem Inflammatory Syndrome in Children (MIS-C) is defined as an individual <21yrs presenting with fever, laboratory evidence of inflammation and evidence of clinically severe illness requiring hospitalization with multisystem (≥= 2) organ involvement( cardiac, renal, respiratory, hematologic, gastrointestinal, dermatologic or neurological) and no alternative plausible diagnosis and Positive for current or recent SARS-CoV2 (COVID 19) infection by Reverse Transcription Polymerase chain Reaction (RT-PCR), serology or antigen test or COVID 19 exposure within the 4 weeks before the onset of symptoms and The most affected age group is 6–10 years. Fever meaning a temperature of >38C for ≥= 24hours or a report of subjective fever lasting ≥= 24hours. Laboratory examination of changes in peripheral blood complete blood count (CBC) parameters during acute Kawasaki disease (KD) shows evidence of inflammation. CBC parameters were collected at the initial, pre-IVIG, and post-IVIG stages. The rank-sum test assessed parameter differences over time, including elevated C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), fibrinogen, ferritin, procalcitonin, D-dimer, lactic acid dehydrogenase (LDH), elevated neutrophils, reduced lymphocytes, and low albumin.

Affiliated Institutions

• Apollo Hospitals IN

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