mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells

Chong Chen; Yu Liu; Yang Liu; Pan Zheng

doi:10.1126/scisignal.2000559

Abstract

Rapamycin reverses aging-related declines in hematopoietic stem cell function.

Keywords

Stem cellRejuvenationHaematopoiesisPI3K/AKT/mTOR pathwayCell biologyHematopoietic stem cellBiologyFunction (biology)Cancer researchSignal transductionGenetics

Affiliated Institutions

University of Michigan US

Related Publications

NF-κB in biology and targeted therapy: new insights and translational implications

Qing Guo , Yizi Jin , Xinyu Chen +6 more

Abstract NF-κB signaling has been discovered for nearly 40 years. Initially, NF-κB signaling was identified as a pivotal pathway in mediating inflammatory responses. However, wi...

2024 Signal Transduction and Targeted Therapy 1119 citations

Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system

Sebastian I. Arriola Apelo , Joshua C. Neuman , Emma L. Baar +6 more

Inhibition of the mechanistic target of rapamycin (mTOR) signaling pathway by the FDA-approved drug rapamycin has been shown to promote lifespan and delay age-related diseases i...

2015 Aging Cell 174 citations

The PD‐1 pathway in tolerance and autoimmunity

Loise M. Francisco , Peter T. Sage , Arlene H. Sharpe

Summary: Regulatory T cells (Tregs) and the PD‐1: PD‐ligand (PD‐L) pathway are both critical to terminating immune responses. Elimination of either can result in the breakdown o...

2010 Immunological Reviews 2221 citations

Phosphorylation of the Translational Repressor PHAS-I by the Mammalian Target of Rapamycin

Gregory J. Brunn , Christine C. Hudson , Aleksandar Sekulić +5 more

The immunosuppressant rapamycin interferes with G 1 -phase progression in lymphoid and other cell types by inhibiting the function of the mammalian target of rapamycin (mTOR). m...

1997 Science 956 citations

Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis

Megan Cully , Han You , Arnold J. Levine +1 more

The tumour-suppressor phosphatase with tensin homology (PTEN) is the most important negative regulator of the cell-survival signalling pathway initiated by phosphatidylinositol ...

2006 Nature reviews. Cancer 1213 citations

Publication Info

Year: 2009
Type: article
Volume: 2
Issue: 98
Pages: ra75-ra75
Citations: 667
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

667

OpenAlex

Cite This

APA Style

                            
                                
                                    Chong Chen, 
                                
                                    Yu Liu, 
                                
                                    Yang Liu
                                
                                et al.
                            
                            (2009). 
                            mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells. 
                            Science Signaling
                            , 2
                            (98)
                            , ra75-ra75.
                            https://doi.org/10.1126/scisignal.2000559
                        

Identifiers

DOI: 10.1126/scisignal.2000559