Mortality and Morbidity in Patients Receiving Encainide, Flecainide, or Placebo

Abstract

There was an excess of deaths due to arrhythmia and deaths due to shock after acute recurrent myocardial infarction in patients treated with encainide or flecainide. Nonlethal events, however, were equally distributed between the active-drug and placebo groups. The mechanisms underlying the excess mortality during treatment with encainide or flecainide remain unknown.

Keywords

FlecainideMedicinePlaceboInternal medicineCardiologyRandomizationMyocardial infarctionAnesthesiaIncidence (geometry)PharmacokineticsRandomized controlled trialAtrial fibrillation

Affiliated Institutions

The Coordinating Center US

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Publication Info

Year: 1991
Type: article
Volume: 324
Issue: 12
Pages: 781-788
Citations: 3193
Access: Closed

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APA Style

                            
                                
                                    Debra S. Echt, 
                                
                                    Philip R. Liebson, 
                                
                                    L. Brent Mitchell
                                
                                et al.
                            
                            (1991). 
                            Mortality and Morbidity in Patients Receiving Encainide, Flecainide, or Placebo. 
                            New England Journal of Medicine
                            , 324
                            (12)
                            , 781-788.
                            https://doi.org/10.1056/nejm199103213241201
                        

Identifiers

DOI: 10.1056/nejm199103213241201