Abstract
For an individual patient, a change in plasma HIV-1 RNA level of 2.5-fold or more probably indicates a true biological change. Monitoring HIV-1 RNA levels and CD4+ lymphocytes before a change in antiretroviral treatment and monitoring HIV-1 RNA levels shortly thereafter improves prediction of disease progression and decline in CD4+ counts for 1 year compared with monitoring CD4+ counts of HIV-1 RNA levels alone. Additional monitoring of infectious HIV-1 titers in mononuclear cells of peripheral blood is not useful.
Keywords
MedicineZidovudineImmunologyDidanosineInternal medicineViral loadLamivudineLymphocyteLentivirusNevirapineImmunopathologyClinical trialViral diseaseVirusAntiretroviral therapy
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Publication Info
- Year
- 1997
- Type
- article
- Volume
- 126
- Issue
- 12
- Pages
- 929-938
- Citations
- 282
- Access
- Closed
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Cite This
Michael D. Hughes
(1997).
Monitoring Plasma HIV-1 RNA Levels in Addition to CD4+ Lymphocyte Count Improves Assessment of Antiretroviral Therapeutic Response.
Annals of Internal Medicine
, 126
(12)
, 929-938.
https://doi.org/10.7326/0003-4819-126-12-199706150-00001
Identifiers
- DOI
- 10.7326/0003-4819-126-12-199706150-00001