Keywords
Epithelial–mesenchymal transitionCell biologyTranscription factorTransdifferentiationBiologyReprogrammingBasic helix-loop-helixCellular differentiationMesenchymal stem cellCellStem cellGeneticsGeneTransition (genetics)DNA-binding protein
Affiliated Institutions
Related Publications
Twist Transcriptionally Up-regulates AKT2 in Breast Cancer Cells Leading to Increased Migration, Invasion, and Resistance to Paclitaxel
Abstract Metastasis, the cardinal feature of malignant tumors, is an important clinical variable in patient prognosis. To understand the basis for metastasis, we systematically ...
Variable β-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment
Invasion and dissemination of well-differentiated carcinomas are often associated with loss of epithelial differentiation and gain of mesenchyme-like capabilities of the tumor c...
The epithelial–mesenchymal transition: new insights in signaling, development, and disease
The conversion of an epithelial cell to a mesenchymal cell is critical to metazoan embryogenesis and a defining structural feature of organ development. Current interest in this...
Biomarkers for epithelial-mesenchymal transitions
Somatic cells that change from one mature phenotype to another exhibit the property of plasticity. It is increasingly clear that epithelial and endothelial cells enjoy some of t...
Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease
The events that convert adherent epithelial cells into individual migratory cells that can invade the extracellular matrix are known collectively as epithelial-mesenchymal trans...
Publication Info
- Year
- 2014
- Type
- review
- Volume
- 15
- Issue
- 3
- Pages
- 178-196
- Citations
- 7885
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
7885
OpenAlex
Cite This
Samy Lamouille,
Jian Xu,
Rik Derynck
(2014).
Molecular mechanisms of epithelial–mesenchymal transition.
Nature Reviews Molecular Cell Biology
, 15
(3)
, 178-196.
https://doi.org/10.1038/nrm3758
Identifiers
- DOI
- 10.1038/nrm3758