Abstract
We report Ca2(+)-induced release of Ca2+ from mitochondria (mCICR) dependent on transitory opening of the permeability transition pore (PTP) operating in a low conductance mode. The Ca2+ fluxes taking place during mCICR are a direct consequence of the mitochondrial depolarization spike (mDPS) caused by PTP opening. Both mDPS and mCICR can propagate from one mitochondrion to another in vitro, generating traveling depolarization and Ca2+ waves. Mitochondria thus appear to be excitable organelles capable of generating and conveying electrical and Ca2+ signals. In living cells, mDPS/mCICR is triggered during IP3-induced Ca2+ mobilization and results in the amplification of the Ca2+ signals primarily emitted from the endoplasmic reticulum.
Keywords
DepolarizationMitochondrionEndoplasmic reticulumBiologyOrganelleBiophysicsConductanceCalciumCalcium signalingMitochondrial permeability transition poreMembrane potentialCell biologyBiochemistryMaterials sciencePhysicsIntracellularProgrammed cell deathApoptosis
MeSH Terms
AnimalsBiological TransportCalciumCarcinomaEhrlich TumorElectric ConductivityElectrophysiologyEndoplasmic ReticulumInositol 145-TrisphosphateMembrane PotentialsMiceMitochondriaSignal TransductionTumor CellsCultured
Affiliated Institutions
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Publication Info
- Year
- 1997
- Type
- article
- Volume
- 89
- Issue
- 7
- Pages
- 1145-1153
- Citations
- 743
- Access
- Closed
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Cite This
François Ichas,
Laurence S. Jouaville,
Jean‐Pierre Mazat
(1997).
Mitochondria Are Excitable Organelles Capable of Generating and Conveying Electrical and Calcium Signals.
Cell
, 89
(7)
, 1145-1153.
https://doi.org/10.1016/s0092-8674(00)80301-3
Identifiers
- DOI
- 10.1016/s0092-8674(00)80301-3
- PMID
- 9215636