Abstract
Observations of apoptosis in virtual anaerobiosis have raised doubts on the significance of reactive oxygen species in the cascade of events of programmed cell death. This work presents evidence that cells and mitochondrial preparations produce similar levels of hydrogen peroxide under either aerobic or virtually anaerobic conditions. These levels are relevant to the increased production of radicals induced by a ceramide analog that promotes apoptosis. This ceramide acts at center o of mitochondrial complex III.
Keywords
CeramideReactive oxygen speciesApoptosisMitochondrionHydrogen peroxideCell biologyAnaerobic exerciseProgrammed cell deathOxygenChemistryBiologyBiochemistryPhysiology
MeSH Terms
AnaerobiosisAnimalsAntimycin AApoptosisCOS CellsCattleCeramidesElectron Transport Complex IIIEnzyme InhibitorsHydrogen PeroxideMitochondriaHeartReactive Oxygen SpeciesStilbenesSubmitochondrial Particles
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Publication Info
- Year
- 1998
- Type
- article
- Volume
- 430
- Issue
- 3
- Pages
- 338-342
- Citations
- 152
- Access
- Closed
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Cite This
Mauro Degli Esposti,
Holly McLennan
(1998).
Mitochondria and cells produce reactive oxygen species in virtual anaerobiosis: relevance to ceramide‐induced apoptosis.
FEBS Letters
, 430
(3)
, 338-342.
https://doi.org/10.1016/s0014-5793(98)00688-7
Identifiers
- DOI
- 10.1016/s0014-5793(98)00688-7
- PMID
- 9688567