Abstract
REVIEW A variety of key events in apoptosis focus on mitochondria, including the release of caspase activators (such as cytochrome c), changes in electron transport, loss of mitochondrial transmembrane potential, altered cellular oxidation-reduction, and participation of pro- and antiapoptotic Bcl-2 family proteins. The different signals that converge on mitochondria to trigger or inhibit these events and their downstream effects delineate several major pathways in physiological cell death.
Keywords
MitochondrionApoptosisCell biologyCytochrome cBcl-2 familyElectron transport chainProgrammed cell deathCaspaseBiologyChemistryBiochemistry
MeSH Terms
AnimalsApoptosisCysteine EndopeptidasesCytochrome c GroupElectron TransportHumansIntracellular MembranesIon ChannelsMembrane PotentialsMitochondriaOxidation-ReductionPermeabilityProto-Oncogene Proteins c-bcl-2
Affiliated Institutions
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Publication Info
- Year
- 1998
- Type
- review
- Volume
- 281
- Issue
- 5381
- Pages
- 1309-1312
- Citations
- 8944
- Access
- Closed
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Cite This
Douglas R. Green,
John C. Reed
(1998).
Mitochondria and Apoptosis.
Science
, 281
(5381)
, 1309-1312.
https://doi.org/10.1126/science.281.5381.1309
Identifiers
- DOI
- 10.1126/science.281.5381.1309
- PMID
- 9721092