Missense mutations of the BRAF gene in human lung adenocarcinoma.

Abstract

Mutations of the BRAF protein serine/threonine kinase gene have recently been identified in a variety of human cancers, most notably melanomas. We sought to determine the frequency of BRAF mutations in human lung cancer pathogenesis. Analysis of BRAF sequence from 127 primary human lung adenocarcinomas revealed mutations in two tumor specimens, one in exon 11 (G465V), and a second in exon 15 (L596R). These specimens belong to the same adenocarcinoma subgroup as defined by clustering of gene expression data. BRAF may provide a target for anticancer chemotherapy in a subset of lung adenocarcinoma patients.

Keywords

ExonAdenocarcinomaMissense mutationCancer researchLung cancerGeneBiologyMutationAdenocarcinoma of the lungCancerGeneticsMedicinePathology

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Publication Info

Year: 2002
Type: article
Volume: 62
Issue: 23
Pages: 7001-3
Citations: 284
Access: Closed

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APA Style

                            
                                    Katsuhiko Naoki, 
                                
                                    Tzu Hsiu Chen, 
                                
                                    William G. Richards
                                
                                et al.
                            
                            (2002). 
                            Missense mutations of the BRAF gene in human lung adenocarcinoma.. 
                            PubMed
                            , 62
                            (23)
                            , 7001-3.