Keywords
BiologymicroRNACaenorhabditis elegansGeneRegulation of gene expressionGeneticsComputational biologyGene expressionCaenorhabditisGenomeRNA interferenceGene familyRNA
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An Abundant Class of Tiny RNAs with Probable Regulatory Roles in <i>Caenorhabditis elegans</i>
Two small temporal RNAs (stRNAs), lin-4 and let-7 , control developmental timing in Caenorhabditis elegans . We find that these two regulatory RNAs are members of a large class ...
Identification of Novel Genes Coding for Small Expressed RNAs
In Caenorhabditis elegans , lin-4 and let-7 encode 22- and 21-nucleotide (nt) RNAs, respectively, which function as key regulators of developmental timing. Because the appearanc...
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Abstract Background MicroRNAs are a large new class of tiny regulatory RNAs found in nematodes, plants, insects and mammals. MicroRNAs are thought to act as post-transcriptional...
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Publication Info
- Year
- 2004
- Type
- review
- Volume
- 5
- Issue
- 7
- Pages
- 522-531
- Citations
- 6947
- Access
- Closed
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Cite This
Lin He,
Gregory J. Hannon
(2004).
MicroRNAs: small RNAs with a big role in gene regulation.
Nature Reviews Genetics
, 5
(7)
, 522-531.
https://doi.org/10.1038/nrg1379
Identifiers
- DOI
- 10.1038/nrg1379