Keywords
MethyltransferaseBiologyCancer researchDNA repairGeneMutagenesisO-6-methylguanine-DNA methyltransferaseGuanineDNACancerGenetic enhancementDNA methylationDNA damageTemozolomideCancer cellGeneticsMethylationGene expressionMutationNucleotideGlioma
Affiliated Institutions
Related Publications
Clinical Trial Substantiates the Predictive Value of <b> <i>O-6-Methylguanine-DNA Methyltransferase</i> </b> Promoter Methylation in Glioblastoma Patients Treated with Temozolomide
Abstract Purpose: In the setting of a prospective clinical trial, we determined the predictive value of the methylation status of the O-6-methylguanine-DNA methyltransferase (MG...
Promoter Hypermethylation of the DNA Repair Gene <i>O</i><sup>6</sup>‐<i>Methylguanine‐DNA Methyltransferase</i> is an Independent Predictor of Shortened Progression Free Survival in Patients with Low‐grade Diffuse Astrocytomas
The O 6 ‐methylguanine‐DNA methyltransferase (MGMT) plays a major role in repairing DNA damage from alkylating agents. In several human neoplasms including low‐grade diffuse ast...
Temozolomide-Mediated Radiation Enhancement in Glioblastoma: A Report on Underlying Mechanisms
Abstract Purpose: In this study, we investigated the mechanisms by which temozolomide enhances radiation response in glioblastoma cells. Experimental Design: Using a panel of fo...
Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia.
The DNA repair protein O6-methylguanine DNA methyltransferase (MGMT) removes alkyl adducts from the O6 position of guanine. MGMT expression is decreased in some tumor tissues, a...
Methylation of Discrete Regions of the <i>O</i><sup>6</sup>-Methylguanine DNA Methyltransferase (MGMT) CpG Island Is Associated with Heterochromatinization of the MGMT Transcription Start Site and Silencing of the Gene
O6-Methylguanine DNA methyltransferase (MGMT) repairs the mutagenic and cytotoxic O6-alkylguanine lesions produced by environmental carcinogens and the chemotherapeutic nitrosou...
Publication Info
- Year
- 2004
- Type
- review
- Volume
- 4
- Issue
- 4
- Pages
- 296-307
- Citations
- 804
- Access
- Closed
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Cite This
Stanton L. Gerson
(2004).
MGMT: its role in cancer aetiology and cancer therapeutics.
Nature reviews. Cancer
, 4
(4)
, 296-307.
https://doi.org/10.1038/nrc1319
Identifiers
- DOI
- 10.1038/nrc1319