Abstract
Clones derived in vitro from a parent culture of murine malignant melanoma cells varied greatly in their ability to produce metastatic colonies in the lungs upon intravenous inoculation into syngeneic mice. This suggests that the parent tumor is heterogeneous and that highly metastatic tumor cell variants preexist in the parental population.
Keywords
In vitroMelanomaMetastasisTumor cellsInoculationPopulationCancer researchMetastatic tumorBiologyCellCell cultureMetastatic melanomaPathologyImmunologyMedicineCancerGenetics
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Publication Info
- Year
- 1977
- Type
- article
- Volume
- 197
- Issue
- 4306
- Pages
- 893-895
- Citations
- 1426
- Access
- Closed
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Cite This
Isaiah J. Fidler,
Margaret L. Kripke
(1977).
Metastasis Results from Preexisting Variant Cells Within a Malignant Tumor.
Science
, 197
(4306)
, 893-895.
https://doi.org/10.1126/science.887927
Identifiers
- DOI
- 10.1126/science.887927