Abstract

This article reviews current knowledge of the metabolism of drugs that contain fluorine. The strategic value of fluorine substitution in drug design is discussed in terms of chemical structure and basic concepts in drug metabolism and drug toxicity.

Keywords

FluorineDrugMetabolismDrug metabolismChemistryPharmacologyBiochemistryMedicineOrganic chemistry

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Publication Info

Year
2001
Type
review
Volume
41
Issue
1
Pages
443-470
Citations
590
Access
Closed

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Bongkyu Park, Neil R. Kitteringham, Paul M. O’Neill (2001). Metabolism of Fluorine-Containing Drugs. The Annual Review of Pharmacology and Toxicology , 41 (1) , 443-470. https://doi.org/10.1146/annurev.pharmtox.41.1.443

Identifiers

DOI
10.1146/annurev.pharmtox.41.1.443