Abstract
Treatment of obese (ob/ob) mice with the beta 3-adrenergic receptor (beta 3-AR) agonist BRL-35135 (1 mg.kg body wt-1.day-1 for 20 days) normalized plasma glucose levels and significantly decreased plasma insulin and nonesterified fatty acid levels. The time frame for the hypoglycemic effect, which reached a maximum after 10 days of treatment, paralleled an increase in brown adipose tissue DNA and protein content. The basal level of mRNA for the beta 3-AR and mitochondrial uncoupling protein was found to be markedly decreased in the ob/ob animals relative to the lean group. Chronic treatment of ob/ob mice for 20 days resulted in a twofold increase in beta 3-AR mRNA and a fivefold increase in uncoupling protein mRNA in brown adipose tissue relative to the placebo group. These findings indicate that chronic treatment of ob/ob animals with a beta 3-AR agonist results in proliferation of brown adipose tissue, with an upregulation of the beta 3-AR, which is associated with a decrease in plasma glucose, insulin, and nonesterified fatty acid levels.
Keywords
EndocrinologyInternal medicineUncoupling proteinAdipose tissueBrown adipose tissueAgonistInsulinReceptorChemistryThermogeninBETA (programming language)Downregulation and upregulationAdrenergic receptorBiologyMedicineGeneBiochemistry
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Publication Info
- Year
- 1995
- Type
- article
- Volume
- 268
- Issue
- 4
- Pages
- E678-E684
- Citations
- 52
- Access
- Closed
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Cite This
Cynthia Arbeeny,
Daniel S. Meyers,
D.E. Hillyer
et al.
(1995).
Metabolic alterations associated with the antidiabetic effect of beta 3-adrenergic receptor agonists in obese mice.
American Journal of Physiology-Endocrinology and Metabolism
, 268
(4)
, E678-E684.
https://doi.org/10.1152/ajpendo.1995.268.4.e678
Identifiers
- DOI
- 10.1152/ajpendo.1995.268.4.e678