Abstract
Mesenchymal stromal cells (MSCs) have been the subject of clinical trials for more than a generation, and the outcomes of advanced clinical trials have fallen short of expectations raised by encouraging pre-clinical animal data in a wide array of disease models. In this Perspective, important biological and pharmacological disparities in pre-clinical research and human translational studies are highlighted, and analyses of clinical trial failures and recent successes provide a rational pathway to MSC regulatory approval and deployment for disorders with unmet medical needs.
Keywords
Mesenchymal stem cellBiologyStromal cellCell biologyComputational biologyBioinformaticsCancer research
MeSH Terms
AnimalsGraft vs Host DiseaseHumansMesenchymal Stem Cell TransplantationMesenchymal Stem Cells
Affiliated Institutions
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Publication Info
- Year
- 2018
- Type
- review
- Volume
- 22
- Issue
- 6
- Pages
- 824-833
- Citations
- 1664
- Access
- Closed
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Cite This
Jacques Galipeau,
Luc Sensebé
(2018).
Mesenchymal Stromal Cells: Clinical Challenges and Therapeutic Opportunities.
Cell stem cell
, 22
(6)
, 824-833.
https://doi.org/10.1016/j.stem.2018.05.004
Identifiers
- DOI
- 10.1016/j.stem.2018.05.004
- PMID
- 29859173
- PMCID
- PMC6434696