Abstract

Mesenchymal stem cells (MSCs) are multilineage cells with the ability to self-renew and differentiate into a variety of cell types, which play key roles in tissue healing and regenerative medicine. Bone marrow-derived mesenchymal stem cells (BMSCs) are the most frequently used stem cells in cell therapy and tissue engineering. However, it is prerequisite for BMSCs to mobilize from bone marrow and migrate into injured tissues during the healing process, through peripheral circulation. The migration of BMSCs is regulated by mechanical and chemical factors in this trafficking process. In this paper, we review the effects of several main regulatory factors on BMSC migration and its underlying mechanism; discuss two critical roles of BMSCs—namely, directed differentiation and the paracrine function—in tissue repair; and provide insight into the relationship between BMSC migration and tissue repair, which may provide a better guide for clinical applications in tissue repair through the efficient regulation of BMSC migration.

Keywords

Mesenchymal stem cellParacrine signallingStem cellCell biologyTissue engineeringRegenerative medicineClinical uses of mesenchymal stem cellsStem cell transplantation for articular cartilage repairBone marrowCell migrationBiologyCellAdult stem cellEndothelial stem cellImmunologyMedicineBiomedical engineeringIn vitro

Affiliated Institutions

Related Publications

Publication Info

Year
2019
Type
review
Volume
8
Issue
8
Pages
784-784
Citations
1006
Access
Closed

External Links

View on DOI.org

Social Impact

Altmetric
PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

1006
OpenAlex

Cite This

Xiaorong Fu, Ge Liu, Alexander Halim et al. (2019). Mesenchymal Stem Cell Migration and Tissue Repair. Cells , 8 (8) , 784-784. https://doi.org/10.3390/cells8080784

Identifiers

DOI
10.3390/cells8080784