Abstract
Most MR studies either use the genotype as a proxy for exposure without further estimation or perform an IV analysis. The discussion of underlying assumptions and reporting of statistical methods for IV analysis are frequently insufficient. Studies using data from multiple study populations are further complicated by the combination of data or estimates. We provide a checklist for the reporting of MR studies.
Keywords
Mendelian randomizationProxy (statistics)Statistical powerConfoundingChecklistMeta-analysisResearch designMEDLINEPopulationMedicineStatisticsClinical study designStudy heterogeneityInstrumental variableSample size determinationEconometricsClinical trialPsychologyGenotypePathologyBiologyCognitive psychologyMathematicsGeneticsGenetic variantsEnvironmental health
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Publication Info
- Year
- 2015
- Type
- review
- Volume
- 44
- Issue
- 2
- Pages
- 496-511
- Citations
- 625
- Access
- Closed
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Cite This
Anna G. C. Boef,
Olaf M. Dekkers,
Saskia le Cessie
(2015).
Mendelian randomization studies: a review of the approaches used and the quality of reporting.
International Journal of Epidemiology
, 44
(2)
, 496-511.
https://doi.org/10.1093/ije/dyv071
Identifiers
- DOI
- 10.1093/ije/dyv071