MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy

Abstract

Background Mucositis is a significant toxicity of cancer therapy with numerous systemic sequelae. The goal of this systematic review was to update the Multinational Association of Supportive Care in Cancer and International Society of Oral Oncology (MASCC/ISOO) Clinical Practice Guidelines for the management of mucositis. Methods The literature was reviewed systematically to identify interventions for mucositis. Studies were rated according to the presence of major and minor flaws according to previously published criteria. The body of evidence for each intervention and in each treatment setting was assigned a level of evidence based on previously published criteria. Guidelines were developed based on the level of evidence, with 3 possible guideline determinations: recommendation , suggestion , or no guideline possible . Results The guideline covers evidence from 1197 publications related to oral or gastrointestinal mucositis. Thirteen new guidelines were developed for or against the use of various interventions in specific treatment settings, and 11 previous guidelines were confirmed after aa review of new evidence. Thirteen previously established guidelines were carried over because there was no new evidence for these interventions. Conclusions The updated MASCC/ISOO Clinical Practice Guidelines for mucositis provide professional health caregivers with a clinical setting‐specific, evidence‐based tool to help with the management of mucositis in patients who have cancer.

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Affiliated Institutions

• University of Rochester Medical Center US
• Sheba Medical Center IL
• Tel Aviv University IL
• The University of Adelaide AU
• UConn Health US
• National University of Singapore SG
• Health Sciences North CA
• Universidade Estadual de Campinas (UNICAMP) BR
• NOSM University CA
• James Cook University AU
• University of Brescia IT
• Mount Sinai Hospital US
• Eastman Chemical Company (United States) US
• Hebrew University of Jerusalem IL

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