Major Outcomes in Moderately Hypercholesterolemic, Hypertensive Patients Randomized to Pravastatin vs Usual Care: The Antihypertensive and...

Abstract

Pravastatin did not reduce either all-cause mortality or CHD significantly when compared with usual care in older participants with well-controlled hypertension and moderately elevated LDL-C. The results may be due to the modest differential in total cholesterol (9.6%) and LDL-C (16.7%) between pravastatin and usual care compared with prior statin trials supporting cardiovascular disease prevention.

Keywords

MedicinePravastatinInternal medicineMyocardial infarctionRandomized controlled trialDiabetes mellitusCholesterolEndocrinology

MeSH Terms

AgedAnticholesteremic AgentsCardiovascular DiseasesCause of DeathFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsHypercholesterolemiaHypertensionLipidsMaleMiddle AgedPravastatinProportional Hazards ModelsRisk Factors

Affiliated Institutions

The University of Texas Health Science Center at Houston US

Related Publications

Effects of blood pressure lowering on outcome incidence in hypertension. 1. Overview, meta-analyses, and meta-regression analyses of randomized trials

Costas Thomopoulos , Gianfranco Parati , Alberto Zanchetti

Meta-analyses of all BP-lowering RCTs involving hypertensive patients provide precise estimates of benefits (larger for stroke and heart failure, but also significant for CHD an...

2014 Journal of Hypertension 364 citations

Effect of Antihypertensive Treatment in Patients Having Already Suffered From Stroke

François Gueyffier , Jean‐Pierre Boissel , Florent Boutitie +10 more

Background and Purpose Drug treatment of high blood pressure has been shown to reduce the associated cardiovascular risk. Stroke represents the type of event more strongly linke...

1997 Stroke 247 citations

Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies

M R Law , Joan K. Morris , Nicholas Wald

With the exception of the extra protective effect of beta blockers given shortly after a myocardial infarction and the minor additional effect of calcium channel blockers in pre...

2009 BMJ 2727 citations

A Comparison of Results of Meta-analyses of Randomized Control Trials and Recommendations of Clinical Experts

Elliott M. Antman

Finding and analyzing all therapeutic trials in a given field has become such a difficult and specialized task that the clinical experts called on to summarize the evidence in a...

1992 JAMA 1459 citations

Publication Info

Year: 2002
Type: article
Volume: 288
Issue: 23
Pages: 2998-3007
Citations: 1323
Access: Closed

External Links

Download PDF (Free) View on DOI.org PubMed Semantic Scholar

Social Impact

Altmetric

Major Outcomes in Moderately Hypercholesterolemic, Hypertensive Patients Randomized to Pravastatin vs Usual Care: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT-LLT)

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

1323

OpenAlex

Influential

1038

CrossRef

Cite This

APA Style

                            
                                
                                    Curt D. Furberg, 
                                
                                    Jackson T. Wright, 
                                
                                    Barry R. Davis
                                
                                et al.
                            
                            (2002). 
                            Major Outcomes in Moderately Hypercholesterolemic, Hypertensive Patients Randomized to Pravastatin vs Usual Care: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT-LLT). 
                            JAMA
                            , 288
                            (23)
                            , 2998-3007.
                            https://doi.org/10.1001/jama.288.23.2998
                        

Identifiers

DOI: 10.1001/jama.288.23.2998
PMID: 12479764

Data Quality

Data completeness: 90%