Abstract
A novel carrier system for the delivery of chemotherapeutic agents by magnetic means to desired sites has been developed. Results indicate that the carrier, albumin microspheres with entrapped Fe3O4, and adriamycin HCl, can be concentrated at a predetermined site in vivo by a magnetic field. Carrier delivery of adriamycin is supported by the presence of a significant concentration of the drug at the site of carrier localization. This delivery system allows for the accumulation of local adriamycin which is comparable to that achieved by administration of a 100-fold higher dose of the free drug.
Keywords
In vivoDrug deliveryMicrosphereDrug carrierCarrier systemDrugDelivery systemChemistryTargeted drug deliveryPharmacologyDoxorubicinBiomedical engineeringNanotechnologyMaterials scienceMedicineChemotherapySurgeryComputer scienceChemical engineeringBiologyEngineeringBiotechnology
MeSH Terms
AnimalsDoxorubicinFemaleInfusionsIntra-ArterialMagneticsMiceMicrospheresModelsBiologicalParticle SizePharmaceutical PreparationsRatsSerum AlbuminTail
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Publication Info
- Year
- 1978
- Type
- article
- Volume
- 158
- Issue
- 2
- Pages
- 141-146
- Citations
- 450
- Access
- Closed
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Cite This
Kenneth J. Widder,
Andrew E. Senyei,
Dante G. Scarpelli
(1978).
Magnetic Microspheres: A Model System for Site Specific Drug Delivery in Vivo.
Experimental Biology and Medicine
, 158
(2)
, 141-146.
https://doi.org/10.3181/00379727-158-40158
Identifiers
- DOI
- 10.3181/00379727-158-40158
- PMID
- 674215