Abstract
CpG dinucleotides are present at the expected frequency in prokaryotic DNA, but are underrepresented ('CpG suppression') and methylated in vertebrate DNA. The vertebrate immune system has apparently evolved the ability to recognize these unmethylated CpG motifs and respond with a rapid and coordinated cytokine response leading to the induction of humoral and cell-mediated immunity.
Keywords
BiologyCpG siteDNACpG OligodeoxynucleotideImmune systemInnate immune systemGeneticsImmunityVertebrateDNA methylationGeneGene expression
MeSH Terms
AnimalsB-LymphocytesBase SequenceDNABacterialDinucleoside PhosphatesHIV-1Lymphocyte ActivationMiceMolecular Sequence DataVirus Diseases
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Publication Info
- Year
- 1996
- Type
- review
- Volume
- 4
- Issue
- 2
- Pages
- 73-77
- Citations
- 125
- Access
- Closed
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Cite This
Arthur Μ. Krieg
(1996).
Lymphocyte activation by CpG dinucleotide motifs in prokaryotic DNA.
Trends in Microbiology
, 4
(2)
, 73-77.
https://doi.org/10.1016/0966-842x(96)81515-0
Identifiers
- DOI
- 10.1016/0966-842x(96)81515-0
- PMID
- 8820571