Low-Dose Methotrexate for the Prevention of Atherosclerotic Events

Paul M. Ridker; Brendan M. Everett; Aruna D. Pradhan; Jean MacFadyen; Daniel H. Solomon; Elaine Zaharris; Virak Mam; Ahmed Hasan; Yves Rosenberg; Erin Iturriaga; Milan Gupta; Michelle Tsigoulis; Subodh Verma; Michael Clearfield; Peter Libby; Samuel Z. Goldhaber; Roger L. Seagle; Cyril Ofori; Mohammad G. Saklayen; Samuel Butman; Narendra Singh; Michel Le May; Olivier F. Bertrand; James Johnston; Nina P. Paynter; Robert J. Glynn

doi:10.1056/nejmoa1809798

Abstract

Among patients with stable atherosclerosis, low-dose methotrexate did not reduce levels of interleukin-1β, interleukin-6, or C-reactive protein and did not result in fewer cardiovascular events than placebo. (Funded by the National Heart, Lung, and Blood Institute; CIRT ClinicalTrials.gov number, NCT01594333.).

Keywords

MethotrexateMedicineInternal medicine

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Publication Info

Year: 2018
Type: article
Volume: 380
Issue: 8
Pages: 752-762
Citations: 1220
Access: Closed

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APA Style

                            
                                
                                    Paul M. Ridker, 
                                
                                    Brendan M. Everett, 
                                
                                    Aruna D. Pradhan
                                
                                et al.
                            
                            (2018). 
                            Low-Dose Methotrexate for the Prevention of Atherosclerotic Events. 
                            New England Journal of Medicine
                            , 380
                            (8)
                            , 752-762.
                            https://doi.org/10.1056/nejmoa1809798
                        

Identifiers

DOI: 10.1056/nejmoa1809798