Keywords
RecombinationDNASister chromatidsBiologyGeneticsSomatic cellDNA replicationCell divisionHomologous recombinationPopulationMutationMolecular biologyChromosomeCellGene
Affiliated Institutions
Related Publications
Poly(ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination
Cells with non-functional poly(ADP-ribose) polymerase (PARP-1) show increased levels of sister chromatid exchange, suggesting a hyper recombination phenotype in these cells. To ...
Telomere length predicts replicative capacity of human fibroblasts.
When human fibroblasts from different donors are grown in vitro, only a small fraction of the variation in their finite replicative capacity is explained by the chronological ag...
Telomere shortening in renal cell carcinoma.
The ends of human chromosomes consist of a specialized structure, the telomere, composed of repeats of TTAGGG making up a total of 5-15 kilobase pairs, depending on age and prol...
Brca2 (XRCC11) Deficiency Results in Radioresistant DNA Synthesis and a Higher Frequency of Spontaneous Deletions
We show here that the radiosensitive Chinese hamster cell mutant (V-C8) of group XRCC11 is defective in the breast cancer susceptibility gene Brca2. The very complex phenotype o...
Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells.
Human diploid fibroblast cells lose replicative potential after a certain number of population doublings. We use this experimental system to investigate the role of oxidative da...
Publication Info
- Year
- 1982
- Type
- article
- Volume
- 94
- Issue
- 1
- Pages
- 1-12
- Citations
- 10
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
10
OpenAlex
Cite This
Calvin B. Harley,
Robert J. Shmookler Reis,
Samuel Goldstein
(1982).
Loss of repetitious DNA in proliferating somatic cells may be due to unequal recombination.
Journal of Theoretical Biology
, 94
(1)
, 1-12.
https://doi.org/10.1016/0022-5193(82)90326-5
Identifiers
- DOI
- 10.1016/0022-5193(82)90326-5