Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients

Abstract

The dynamic changes of lymphocyte subsets and cytokines profiles of patients with novel coronavirus disease (COVID-19) and their correlation with the disease severity remain unclear. Peripheral blood samples were longitudinally collected from 40 confirmed COVID-19 patients and examined for lymphocyte subsets by flow cytometry and cytokine profiles by specific immunoassays. The degree of lymphopenia and a proinflammatory cytokine storm is higher in severe COVID-19 patients than in mild cases, and is associated with the disease severity. N8R and NLR may serve as a useful prognostic factor for early identification of severe COVID-19 cases. The National Natural Science Foundation of China, the National Science and Technology Major Project, the Health Commission of Hubei Province, Huazhong University of Science and Technology, and the Medical Faculty of the University of Duisburg-Essen and Stiftung Universitaetsmedizin, Hospital Essen, Germany.

Keywords

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)ImmunologyPeripheral bloodMedicineCoronavirus disease 2019 (COVID-19)2019-20 coronavirus outbreakPeripheralCytokineLymphocyteVirologyBetacoronavirusPathologyInternal medicineDiseaseInfectious disease (medical specialty)Outbreak

MeSH Terms

AdultAgedBetacoronavirusCD8-Positive T-LymphocytesCOVID-19ChinaComorbidityCoronavirus InfectionsCytokine Release SyndromeCytokinesFemaleFlow CytometryHumansLeukocyte CountLymphocyte CountLymphocyte SubsetsLymphopeniaMaleMiddle AgedNeutrophilsPandemicsPneumoniaViralPrognosisSARS-CoV-2Time Factors

Affiliated Institutions

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Publication Info

Year: 2020
Type: article
Volume: 55
Pages: 102763-102763
Citations: 1716
Access: Closed

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APA Style

                            
                                    Jing Liu, 
                                
                                    Sumeng Li, 
                                
                                    Jia Liu
                                
                                et al.
                            
                            (2020). 
                            Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients. 
                            EBioMedicine
                            , 55
                            
                            , 102763-102763.
                            https://doi.org/10.1016/j.ebiom.2020.102763

Identifiers

DOI: 10.1016/j.ebiom.2020.102763
PMID: 32361250
PMCID: PMC7165294

Data Quality

Data completeness: 90%