Localized Oncolytic Virotherapy Overcomes Systemic Tumor Resistance to Immune Checkpoint Blockade Immunotherapy

Abstract

Intratumoral treatment with an oncolytic virus results in inflammatory infiltrates in distant tumors and sensitizes the tumors to immune-mediated rejection in the setting of immunotherapy with CTLA-4 blocking antibodies.

Keywords

Oncolytic virusImmunotherapyImmune systemMedicineImmune checkpointCD8ImmunologyCancer researchBlockadeMelanomaCytotoxic T cellBiologyInternal medicineReceptor

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Publication Info

Year: 2014
Type: article
Volume: 6
Issue: 226
Pages: 226ra32-226ra32
Citations: 682
Access: Closed

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APA Style

                            
                                
                                    Dmitriy Zamarin, 
                                
                                    Rikke Holmgaard, 
                                
                                    Sumit K. Subudhi
                                
                                et al.
                            
                            (2014). 
                            Localized Oncolytic Virotherapy Overcomes Systemic Tumor Resistance to Immune Checkpoint Blockade Immunotherapy. 
                            Science Translational Medicine
                            , 6
                            (226)
                            , 226ra32-226ra32.
                            https://doi.org/10.1126/scitranslmed.3008095
                        

Identifiers

DOI: 10.1126/scitranslmed.3008095