Leukocyte matrices in the technology of personalized assessment of immune status in sepsis

Abstract

Sepsis remains a global medical and social problem and a leading cause of mortality. Sepsis is characterized by life-threatening organ dysfunction caused by a dysregulated immune response to infection. The current understanding of sepsis pathophysiology has shifted from studying the pathogen to analyzing the patient's immune response, which is characterized by significant heterogeneity and individuality. In general, sepsis is characterized by the simultaneous or sequential development of hyperinflammation and immunosuppression, which ultimately determines the clinical outcome. This article emphasizes the need for a personalized approach to sepsis treatment based on the diagnosis of the patient's immune status. We propose evaluating complete blood count parameters using calculated leukocyte matrices as an accessible, reproducible, and pathogenetically validated tool, allowing for a quantitative assessment of the type and nature of the immune response. A method for interpreting leukocyte matrices using the "Sepsis Immunotyping Technology" is presented to determine the activation of innate or adaptive immunity, as well as unresponsiveness or immunosuppression. We conclude that this approach has clinical significance for predicting the course of the disease and selecting rational immune-based therapy.

Affiliated Institutions

• Siberian Branch of the Russian Academy of Sciences RU
• Research Institute of Medical Problems of the North RU
• Krasnoyarsk Scientific Center RU
• Krasnoyarsk State Medical University RU

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