Abstract
Leukocyte adhesion deficiency (LAD) is a recently recognized autosomal-recessive trait characterized by recurrent bacterial infections, impaired pus formation and wound healing, and abnormalities in a wide spectrum of adherence-dependent functions of granulocytes, monocytes, and lymphoid cells. Features of this disease are attributable to deficiency (or absence) of cell surface expression of a family of functionally and structurally related glycoproteins. These include Mac-1 (complement receptor type 3), lymphocyte function-associated antigen-1 (LFA-1), and p150,95. Defective biosynthesis of the beta chain shared by each molecule (comprised of alpha 1 beta 1 complexes) represents the fundamental molecular basis of this disease. Recognition of the molecular pathogenesis of this disorder has allowed rich insights into the role of cellular adherence reactions in inflammation and host defense.
Keywords
Leukocyte adhesion deficiencyImmunologyPathogenesisGlycoproteinInflammationBiologyCell adhesion moleculeDiseaseCell adhesionAntibodyCellGeneticsMedicineCD18Pathology
Related Publications
Primary structure of the leukocyte function-associated molecule-1 alpha subunit: an integrin with an embedded domain defining a protein superfamily.
The leukocyte function-associated molecule 1 (LFA-1, CD11a/CD18) is a membrane glycoprotein which functions in cell-cell adhesion by heterophilic interaction with intercellular ...
The I domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b/CD18) for four distinct adhesion ligands.
Despite the identification and characterization of several distinct ligands for the leukocyte integrin (CD11/CD18) family of adhesion receptors, little is known about the struct...
Characterization of the function of intercellular adhesion molecule (ICAM)-3 and comparison with ICAM-1 and ICAM-2 in immune responses.
We have characterized the immunobiology of the interaction of intercellular adhesion molecule 3 (ICAM-3; CD50) with its counter-receptor, leukocyte function-associated antigen 1...
Of Man and Mouse: Leukocyte and Endothelial Adhesion Molecule Deficiencies
“It is in her moments of abnormalities that nature reveals its secrets.” (Goethe) I MPORTANT INSIGHTS into a number of biological processes have come from studies of rare inher...
Constitutive and stimulus-induced phosphorylation of CD11/CD18 leukocyte adhesion molecules.
The leukocyte CD11/CD18 adhesion molecules (beta 2 integrins) are a family of three heterodimeric glycoproteins each with a distinct alpha subunit (CD11a, b, or c) and a common ...
Publication Info
- Year
- 1987
- Type
- article
- Volume
- 38
- Issue
- 1
- Pages
- 175-194
- Citations
- 1143
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
1143
OpenAlex
Cite This
D. C. Anderson,
Timothy A. Springer
(1987).
LEUKOCYTE ADHESION DEFICIENCY: An Inherited Defect in the Mac-1, LFA-1, and p150,95 Glycoproteins.
Annual Review of Medicine
, 38
(1)
, 175-194.
https://doi.org/10.1146/annurev.me.38.020187.001135
Identifiers
- DOI
- 10.1146/annurev.me.38.020187.001135