KTE-X19 CAR T-Cell Therapy in Relapsed or Refractory Mantle-Cell Lymphoma

2020 New England Journal of Medicine 1,666 citations

Abstract

KTE-X19 induced durable remissions in a majority of patients with relapsed or refractory mantle-cell lymphoma. The therapy led to serious and life-threatening toxic effects that were consistent with those reported with other CAR T-cell therapies. (Funded by Kite, a Gilead company; ZUMA-2 ClinicalTrials.gov number, NCT02601313.).

Keywords

Mantle cell lymphomaRefractory (planetary science)MedicineLymphomaCancer researchMaterials scienceInternal medicineMetallurgy

MeSH Terms

AdultAgedAntigensCD19Antineoplastic AgentsCombined Modality TherapyHumansImmunotherapyAdoptiveInfusionsIntravenousLeukapheresisLymphomaMantle-CellMiddle AgedReceptorsChimeric AntigenRecurrenceSurvival AnalysisT-LymphocytesVidarabine

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Publication Info

Year
2020
Type
article
Volume
382
Issue
14
Pages
1331-1342
Citations
1666
Access
Closed

Social Impact

Social media, news, blog, policy document mentions

Citation Metrics

1666
OpenAlex
51
Influential
1520
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Cite This

Michael Wang, Javier Muñoz, André Goy et al. (2020). KTE-X19 CAR T-Cell Therapy in Relapsed or Refractory Mantle-Cell Lymphoma. New England Journal of Medicine , 382 (14) , 1331-1342. https://doi.org/10.1056/nejmoa1914347

Identifiers

DOI
10.1056/nejmoa1914347
PMID
32242358
PMCID
PMC7731441

Data Quality

Data completeness: 90%