ISOLATION OF A TUMOR FACTOR RESPONSIBLE FOR ANGIOGENESIS

Abstract

Human and animal solid tumors elaborate a factor which is mitogenic to capillary endothelial cells. This factor has been called tumor-angiogenesis factor. The important components of TAF are RNA and protein. It is suggested that blockade of this factor (inhibition of angiogenesis) might arrest solid tumors at a tiny diameter of a few millimeters.

Keywords

AngiogenesisBlockadeCancer researchBiologyCell biologyNeovascularizationVascular endothelial growth factor AVascular endothelial growth factorVEGF receptorsReceptorGenetics

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Publication Info

Year: 1971
Type: article
Volume: 133
Issue: 2
Pages: 275-288
Citations: 1655
Access: Closed

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APA Style

                            
                                
                                    Judah Folkman, 
                                
                                    Ezio Merler, 
                                
                                    Charles M. Abernathy
                                
                                et al.
                            
                            (1971). 
                            ISOLATION OF A TUMOR FACTOR RESPONSIBLE FOR ANGIOGENESIS. 
                            The Journal of Experimental Medicine
                            , 133
                            (2)
                            , 275-288.
                            https://doi.org/10.1084/jem.133.2.275
                        

Identifiers

DOI: 10.1084/jem.133.2.275