Isolation and Characterization of Viruses Related to the SARS Coronavirus from Animals in Southern China

Abstract

A novel coronavirus (SCoV) is the etiological agent of severe acute respiratory syndrome (SARS). SCoV-like viruses were isolated from Himalayan palm civets found in a live-animal market in Guangdong, China. Evidence of virus infection was also detected in other animals (including a raccoon dog, Nyctereutes procyonoides ) and in humans working at the same market. All the animal isolates retain a 29-nucleotide sequence that is not found in most human isolates. The detection of SCoV-like viruses in small, live wild mammals in a retail market indicates a route of interspecies transmission, although the natural reservoir is not known.

Keywords

BiologyVirologyCoronavirusRaccoon DogsIsolation (microbiology)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Transmission (telecommunications)VirusCoronavirus disease 2019 (COVID-19)ZoologyMicrobiologyInfectious disease (medical specialty)DiseaseMedicine

MeSH Terms

Amino Acid SequenceAnimalsAnimalsWildAntibodiesViralBlottingWesternCarnivoraChinaCoronavirusCoronavirus InfectionsDisease ReservoirsFecesGenomeViralHumansMembrane GlycoproteinsMolecular Sequence DataNeutralization TestsNoseOpen Reading FramesPhylogenyPolymorphismGeneticReverse Transcriptase Polymerase Chain ReactionSevere acute respiratory syndrome-related coronavirusSequence DeletionSequence HomologyNucleic AcidSpike GlycoproteinCoronavirusViral Envelope ProteinsViral Proteins

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Publication Info

Year: 2003
Type: article
Volume: 302
Issue: 5643
Pages: 276-278
Citations: 2458
Access: Closed

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APA Style

                            
                                
                                    Yi Guan, 
                                
                                    Bingxue Zheng, 
                                
                                    Yuxian He
                                
                                et al.
                            
                            (2003). 
                            Isolation and Characterization of Viruses Related to the SARS Coronavirus from Animals in Southern China. 
                            Science
                            , 302
                            (5643)
                            , 276-278.
                            https://doi.org/10.1126/science.1087139
                        

Identifiers

DOI: 10.1126/science.1087139
PMID: 12958366

Data Quality

Data completeness: 81%