Introducing Critical Appraisal to studies of animal models investigating novel therapies in sepsis

R. D. Piper; Deborah J. Cook; Roger C. Bone; William J. Sibbald

doi:10.1097/00003246-199612000-00021

Abstract

The success of clinical trials of sepsis therapies is predicated on the generation and interpretation of sound preclinical data. In this review, we have attempted to outline an evidence-based approach to the assessment of preclinical animal studies evaluating novel therapeutic interventions in sepsis.

Keywords

MedicineCritical appraisalClinical trialIntensive care medicineClinical study designSepsisData extractionMEDLINEAnimal modelAlternative medicineSurgeryPathologyInternal medicine

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Publication Info

Year: 1996
Type: review
Volume: 24
Issue: 12
Pages: 2059-2070
Citations: 133
Access: Closed

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APA Style

                            
                                
                                    R. D. Piper, 
                                
                                    Deborah J. Cook, 
                                
                                    Roger C. Bone
                                
                                et al.
                            
                            (1996). 
                            Introducing Critical Appraisal to studies of animal models investigating novel therapies in sepsis. 
                            Critical Care Medicine
                            , 24
                            (12)
                            , 2059-2070.
                            https://doi.org/10.1097/00003246-199612000-00021
                        

Identifiers

DOI: 10.1097/00003246-199612000-00021