Abstract

ABSTRACT: Intestinal morphogenesis, as well as maintenance of the stem cell population and of the steady state between cell proliferation and differentiation, results from controlled cell interactions. There is growing evidence that the mesenchymal cells control epithelial cell behavior via their own expression and induction in the epithelial cells of key regulatory genes. This heterologous cross talk involves basement membrane molecules and paracrine factors. New in vitro/in vivo cellular models allowed us to analyze various mesenchymal cell phenotypes and to show that they exhibit different inductive properties on epithelial cells and that their proliferation and metabolic properties are differentially modulated by cytokines. Finally the epithelial‐mesenchymal unit is controlled by hormonal and exogenous factors.

Keywords

Mesenchymal stem cellCell biologyParacrine signallingCellBiologyChemistryReceptorGenetics

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Publication Info

Year
1998
Type
review
Volume
859
Issue
1
Pages
1-17
Citations
129
Access
Closed

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M. Kédinger, Isabelle Duluc, Christine Fritsch et al. (1998). Intestinal Epithelial‐Mesenchymal Cell Interactions. Annals of the New York Academy of Sciences , 859 (1) , 1-17. https://doi.org/10.1111/j.1749-6632.1998.tb11107.x

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DOI
10.1111/j.1749-6632.1998.tb11107.x