Abstract

Interleukin 10 (IL-10), originally identified as a TH2 helper T-cell product able to inhibit cytokine production by TH1 cells, is highly homologous to BCRF1 (viral IL-10), an open reading frame in the Epstein-Barr virus genome. Here, we show that human and viral IL-10 stimulate DNA replication of B lymphocytes activated either via their antigen receptor or via their CD40 antigen. IL-4 and IL-10 display additive effects and induce a strong increase in the number of viable cells. Moreover, IL-10 induces activated B cells to secrete large amounts of IgG, IgA, and IgM, and the combination of IL-10 and IL-4 results in the secretion of the four immunoglobulin isotypes. Thus, IL-10 may play an important role in the amplification of humoral responses.

Keywords

BiologyCD40SecretionAntigenCytokineAntibodyMolecular biologyImmunologyCytotoxic T cellIn vitroBiochemistry

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Publication Info

Year
1992
Type
article
Volume
89
Issue
5
Pages
1890-1893
Citations
1240
Access
Closed

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F Rousset, Elisabeth Garcia, Thierry Defrance et al. (1992). Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes.. Proceedings of the National Academy of Sciences , 89 (5) , 1890-1893. https://doi.org/10.1073/pnas.89.5.1890

Identifiers

DOI
10.1073/pnas.89.5.1890