Interleukin-10-deficient mice develop chronic enterocolitis

Ralf Kühn; Jürgen Löhler; D Rennick; Klaus Rajewsky; Werner Müller

doi:10.1016/0092-8674(93)80068-p

Keywords

BiologyImmunologyInflammationImmune systemEnterocolitisMajor histocompatibility complexAntigenInternal medicine

Affiliated Institutions

Related Publications

An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation

Chrystelle Asseman , Smita Mauze , Michael W. Leach +2 more

A T helper cell type 1–mediated colitis develops in severe combined immunodeficient mice after transfer of CD45RBhigh CD4+ T cells and can be prevented by cotransfer of the CD45...

1999 The Journal of Experimental Medicine 1573 citations

Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses.

Daniel Berg , N Davidson , Ralf Kühn +6 more

We have characterized the progressive stages of chronic intestinal inflammation that develops spontaneously in specific pathogen-free (SPF) mice with a targeted disruption in th...

1996 Journal of Clinical Investigation 1129 citations

Differential Cytokine Requirements for Regulation of Autoimmune Gastritis and Colitis by CD4+CD25+T Cells

Elisabeth Suri‐Payer , Harvey Cantor

Murine autoimmune gastritis, induced by neonatal thymectomy or the injection of CD25-depleted lymphocytes into nu/nu recipients, is characterized by an inflammatory infiltrate i...

2001 Journal of Autoimmunity 233 citations

Expression profiling of IL‐10‐regulated genes in human monocytes and peripheral blood mononuclear cells from psoriatic patients during IL‐10 therapy

Mechthild Jung , Robert Sabat , Jörn Krätzschmar +9 more

Abstract Interleukin‐10 (IL‐10), originally identified as an inhibitor of pro‐inflammatory cytokine production, exerts multiple immunomodulatory functions. Its ability to inhibi...

2004 European Journal of Immunology 87 citations

Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.

René de Waal Malefyt , John B.A.G. Haanen , Hergen Spits +7 more

Interleukin 10 (IL-10) and viral IL-10 (v-IL-10) strongly reduced antigen-specific proliferation of human T cells and CD4+ T cell clones when monocytes were used as antigen-pres...

1991 The Journal of Experimental Medicine 1939 citations

Publication Info

Year: 1993
Type: article
Volume: 75
Issue: 2
Pages: 263-274
Citations: 4245
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Interleukin-10-deficient mice develop chronic enterocolitis

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

4245

OpenAlex

Cite This

APA Style

                            
                                
                                    Ralf Kühn, 
                                
                                    Jürgen Löhler, 
                                
                                    D Rennick
                                
                                et al.
                            
                            (1993). 
                            Interleukin-10-deficient mice develop chronic enterocolitis. 
                            Cell
                            , 75
                            (2)
                            , 263-274.
                            https://doi.org/10.1016/0092-8674(93)80068-p
                        

Identifiers

DOI: 10.1016/0092-8674(93)80068-p