Abstract

Interleukin-10 (IL-10), first recognized for its ability to inhibit activation and effector function of T cells, monocytes, and macrophages, is a multifunctional cytokine with diverse effects on most hemopoietic cell types. The principal routine function of IL-10 appears to be to limit and ultimately terminate inflammatory responses. In addition to these activities, IL-10 regulates growth and/or differentiation of B cells, NK cells, cytotoxic and helper T cells, mast cells, granulocytes, dendritic cells, keratinocytes, and endothelial cells. IL-10 plays a key role in differentiation and function of a newly appreciated type of T cell, the T regulatory cell, which may figure prominently in control of immune responses and tolerance in vivo. Uniquely among hemopoietic cytokines, IL-10 has closely related homologs in several virus genomes, which testify to its crucial role in regulating immune and inflammatory responses. This review highlights findings that have advanced our understanding of IL-10 and its receptor, as well as its in vivo function in health and disease.

Keywords

BiologyCytotoxic T cellInterleukin 3Cell biologyImmune systemImmunologyCytokineHaematopoiesisIL-2 receptorInnate lymphoid cellInterleukin 21T cellInnate immune systemStem cellIn vitroGenetics

Related Publications

Blockade of Interleukin-6 Signaling Suppresses Not Only Th17 but Also Interphotoreceptor Retinoid Binding Protein–Specific Th1 by Promoting Regulatory T Cells in Experimental Autoimmune Uveoretinitis

Hiroshi Haruta , Nobuyuki Ohguro , Minoru Fujimoto +7 more

PURPOSE. Both Th17 and Th1 cells contribute to experimental autoimmune uveoretinitis (EAU). Interleukin-6 (IL-6) blockade inhibits Th17 differentiation in EAU and potently suppr...

2011 Investigative Ophthalmology & Visual ... 73 citations

Publication Info

Year
2001
Type
review
Volume
19
Issue
1
Pages
683-765
Citations
6578
Access
Closed

External Links

View on DOI.org

Social Impact

Altmetric
PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

6578
OpenAlex

Cite This

Kevin W. Moore, René de Waal Malefyt, Robert L. Coffman et al. (2001). Interleukin-10 and the Interleukin-10 Receptor. Annual Review of Immunology , 19 (1) , 683-765. https://doi.org/10.1146/annurev.immunol.19.1.683

Identifiers

DOI
10.1146/annurev.immunol.19.1.683