Abstract

We have characterized the mast cell stimulating activity of murine cytokine synthesis inhibitory factor, referred to as interleukin 10 (IL-10). It was found that IL-10 alone failed to support the growth of mast cell lines and mast cell progenitors. Nevertheless, it dramatically enhanced their growth when combined with IL-3 or IL-4. Moreover, IL-4 plus IL-10 supported the proliferation of mast cells as well as IL-3, suggesting that these two factors may provide a pathway for their development independent of IL-3. However, optimal mast cell growth was stimulated by the combination of IL-10, IL-4, and IL-3. This particular set of cytokines are coordinately produced by activated T cells and may constitute an effective network regulating early and late stages of mast cell development during certain immune responses.

Keywords

Mast cellInterleukin 33CytokineProgenitor cellInterleukin 3Cell biologyBiologyInterleukin 5ImmunologyStem cell factorImmune systemInterleukin 4InterleukinInterleukin 9T cellStem cellInterleukin 21

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Publication Info

Year
1991
Type
article
Volume
173
Issue
2
Pages
507-510
Citations
506
Access
Closed

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LuAnn Thompson-Snipes, Vineeta Dhar, M W Bond et al. (1991). Interleukin 10: a novel stimulatory factor for mast cells and their progenitors.. The Journal of Experimental Medicine , 173 (2) , 507-510. https://doi.org/10.1084/jem.173.2.507

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DOI
10.1084/jem.173.2.507