Interleukin-1 Receptor Blockade Is Associated With Reduced Mortality in Sepsis Patients With Features of Macrophage Activation Syndrome

Abstract

In this subgroup analysis, interleukin-1 receptor blockade was associated with significant improvement in survival of patients with sepsis and concurrent hepatobiliary dysfunction/disseminated intravascular coagulation. A prospective randomized trial using features of macrophage activation syndrome for mortality risk stratification should be undertaken to confirm the role of interleukin-1 blockage.

Keywords

AnakinraMedicineDisseminated intravascular coagulationSepsisInternal medicineGastroenterologyMacrophage activation syndromeOrgan dysfunctionSeptic shockSurgeryDisease

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Publication Info

Year: 2015
Type: article
Volume: 44
Issue: 2
Pages: 275-281
Citations: 802
Access: Closed

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APA Style

                            
                                
                                    Bita Shakoory, 
                                
                                    Joseph A. Carcillo, 
                                
                                    W. Winn Chatham
                                
                                et al.
                            
                            (2015). 
                            Interleukin-1 Receptor Blockade Is Associated With Reduced Mortality in Sepsis Patients With Features of Macrophage Activation Syndrome. 
                            Critical Care Medicine
                            , 44
                            (2)
                            , 275-281.
                            https://doi.org/10.1097/ccm.0000000000001402
                        

Identifiers

DOI: 10.1097/ccm.0000000000001402