Abstract
Modern neuroimaging techniques use signals originating from microcirculation to map brain function. In this study, activity-dependent changes in oxyhemoglobin, deoxyhemoglobin, and light scattering were characterized by an imaging spectroscopy approach that offers high spatial, temporal, and spectral resolution. Sensory stimulation of cortical columns initiates tissue hypoxia and vascular responses that occur within the first 3 seconds and are highly localized to individual cortical columns. However, the later phase of the vascular response is less localized, spreading over distances of 3 to 5 millimeters.
Keywords
MicrocirculationNeuroimagingNeuroscienceBrain functionStimulationSensory systemFunctional near-infrared spectroscopyBrain mappingNuclear magnetic resonanceBiologyMedicinePhysicsInternal medicineCognition
MeSH Terms
AnimalsBrain MappingCatsElectrophysiologyHemoglobinsLightMicrocirculationOxyhemoglobinsPhotic StimulationRandom AllocationScatteringRadiationTime FactorsVisual Cortex
Affiliated Institutions
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Publication Info
- Year
- 1996
- Type
- article
- Volume
- 272
- Issue
- 5261
- Pages
- 551-554
- Citations
- 1092
- Access
- Closed
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Cite This
Dov Malonek,
Amiram Grinvald
(1996).
Interactions Between Electrical Activity and Cortical Microcirculation Revealed by Imaging Spectroscopy: Implications for Functional Brain Mapping.
Science
, 272
(5261)
, 551-554.
https://doi.org/10.1126/science.272.5261.551
Identifiers
- DOI
- 10.1126/science.272.5261.551
- PMID
- 8614805