In situ click chemistry generation of cyclooxygenase-2 inhibitors

Keywords

CyclooxygenaseIsozymeIn vivoChemistryClick chemistryDrug discoveryGene isoformBiochemistryEnzymeComputational biologyCombinatorial chemistryBiologyBiotechnologyGene

Affiliated Institutions

University of Alberta CA

Related Publications

Cyclooxygenases: Structural, Cellular, and Molecular Biology

William L. Smith , David L. DeWitt , R. Michael Garavito

▪ Abstract The prostaglandin endoperoxide H synthases-1 and 2 (PGHS-1 and PGHS-2; also cyclooxygenases-1 and 2, COX-1 and COX-2) catalyze the committed step in prostaglandin syn...

2000 Annual Review of Biochemistry 2883 citations

Cyclooxygenase-2: Potential Role in Regulation of Drug Efflux and Multidrug Resistance Phenotype

Andrey Sorokin

Multidrug resistance (MDR) of cancer cells to cytostatic agents is the major obstacle for the succesfull chemotherapy. One of the causes of the development of cellular resistanc...

2004 Current Pharmaceutical Design 83 citations

Solid Phase Combinatorial Library of Phosphinic Peptides for Discovery of Matrix Metalloproteinase Inhibitors

Jens Buchardt , Christine Bruun Schiødt , Christian Krog-Jensen +3 more

A solid phase combinatorial library of 165,000 phosphinic peptide inhibitors was prepared and screened for activity against MMP-12. The inhibitors of the library had the structu...

2000 Journal of Combinatorial Chemistry 59 citations

Novel Peptide Inhibitors of Angiotensin-converting Enzyme 2

Lili Huang , Daniel J. Sexton , Kirsten Skogerson +13 more

Angiotensin-converting enzyme 2 (ACE2), a recently identified human homolog of ACE, is a novel metallocarboxypeptidase with specificity, tissue distribution, and function distin...

2003 Journal of Biological Chemistry 219 citations

3,4-Dihydroxychalcones as potent 5-lipoxygenase and cyclooxygenase inhibitors

Satoshi Sogawa , Yasunori Nihro , Hiroki Ueda +4 more

A novel series of 3,4-dihydroxychalcones was synthesized to evaluate their effects against 5-lipoxygenase and cyclooxygenase. Almost all compounds exhibited potent inhibitory ef...

1993 Journal of Medicinal Chemistry 97 citations

Publication Info

Year: 2017
Type: article
Volume: 8
Issue: 1
Pages: 1-1
Citations: 7378
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

In situ click chemistry generation of cyclooxygenase-2 inhibitors

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

7378

OpenAlex

Cite This

APA Style

                            
                                
                                    Atul Bhardwaj, 
                                
                                    Jatinder Kaur, 
                                
                                    Melinda Wuest
                                
                                et al.
                            
                            (2017). 
                            In situ click chemistry generation of cyclooxygenase-2 inhibitors. 
                            Nature Communications
                            , 8
                            (1)
                            , 1-1.
                            https://doi.org/10.1038/s41467-016-0009-6
                        

Identifiers

DOI: 10.1038/s41467-016-0009-6