Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

2011 New England Journal of Medicine 7,590 citations

Abstract

Vemurafenib produced improved rates of overall and progression-free survival in patients with previously untreated melanoma with the BRAF V600E mutation. (Funded by Hoffmann-La Roche; BRIM-3 ClinicalTrials.gov number, NCT01006980.).

Keywords

VemurafenibMedicineDacarbazineInterim analysisInternal medicineAdverse effectMelanomaOncologyRashDabrafenibProgression-free survivalNauseaClinical trialCancer researchMetastatic melanomaChemotherapyCancer

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Publication Info

Year
2011
Type
article
Volume
364
Issue
26
Pages
2507-2516
Citations
7590
Access
Closed

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Paul B. Chapman, Axel Hauschild, Caroline Robert et al. (2011). Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation. New England Journal of Medicine , 364 (26) , 2507-2516. https://doi.org/10.1056/nejmoa1103782

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DOI
10.1056/nejmoa1103782