Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis

Nathalie Auphan‐Anezin; Joseph A. DiDonato; Caridad Rosette; Arno Helmberg; Michael Karin

doi:10.1126/science.270.5234.286

Abstract

Glucocorticoids are among the most potent anti-inflammatory and immunosuppressive agents. They inhibit synthesis of almost all known cytokines and of several cell surface molecules required for immune function, but the mechanism underlying this activity has been unclear. Here it is shown that glucocorticoids are potent inhibitors of nuclear factor kappa B (NF-κB) activation in mice and cultured cells. This inhibition is mediated by induction of the IκBα inhibitory protein, which traps activated NF-κB in inactive cytoplasmic complexes. Because NF-κB activates many immunoregulatory genes in response to pro-inflammatory stimuli, the inhibition of its activity can be a major component of the anti-inflammatory activity of glucocorticoids.

Keywords

NFKB1NF-κBImmune systemInhibitory postsynaptic potentialGlucocorticoidChemistryIκBαKappaB cellFunction (biology)Cell biologyBiologyPharmacologyInflammationImmunologyTranscription factorGeneEndocrinologyBiochemistryAntibody

Affiliated Institutions

University of California, San Diego US

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Publication Info

Year: 1995
Type: article
Volume: 270
Issue: 5234
Pages: 286-290
Citations: 2389
Access: Closed

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APA Style

                            
                                
                                    Nathalie Auphan‐Anezin, 
                                
                                    Joseph A. DiDonato, 
                                
                                    Caridad Rosette
                                
                                et al.
                            
                            (1995). 
                            Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis. 
                            Science
                            , 270
                            (5234)
                            , 286-290.
                            https://doi.org/10.1126/science.270.5234.286
                        

Identifiers

DOI: 10.1126/science.270.5234.286