Abstract

Dendritic cells (DCs) are antigen-presenting cells with a unique ability to induce primary immune responses. DCs capture and transfer information from the outside world to the cells of the adaptive immune system. DCs are not only critical for the induction of primary immune responses, but may also be important for the induction of immunological tolerance, as well as for the regulation of the type of T cell–mediated immune response. Although our understanding of DC biology is still in its infancy, we are now beginning to use DC-based immunotherapy protocols to elicit immunity against cancer and infectious diseases.

Keywords

BiologyImmune systemImmunologyDendritic cellAcquired immune systemImmunotherapyImmunityImmune toleranceAntigenAntigen-presenting cellT cell

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Publication Info

Year
2000
Type
review
Volume
18
Issue
1
Pages
767-811
Citations
6577
Access
Closed

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Jacques Banchereau, Francine Brière, Christophe Caux et al. (2000). Immunobiology of Dendritic Cells. Annual Review of Immunology , 18 (1) , 767-811. https://doi.org/10.1146/annurev.immunol.18.1.767

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DOI
10.1146/annurev.immunol.18.1.767