Abstract
There is now overwhelming experimental and clinical evidence that atherosclerosis is a chronic inflammatory disease. Lessons from genome-wide association studies, advanced in vivo imaging techniques, transgenic lineage tracing mice, and clinical interventional studies have shown that both innate and adaptive immune mechanisms can accelerate or curb atherosclerosis. Here, we summarize and discuss the pathogenesis of atherosclerosis with a focus on adaptive immunity. We discuss some limitations of animal models and the need for models that are tailored to better translate to human atherosclerosis and ultimately progress in prevention and treatment.
Keywords
adaptive immunityatherosclerosisimmunityinflammationmyeloid cellsvaccination
MeSH Terms
Adaptive ImmunityAnimalsAtherosclerosisDisease ModelsAnimalHumansInflammationInflammation MediatorsMicePlaqueAtheroscleroticSignal TransductionSpecies Specificity
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Publication Info
- Year
- 2019
- Type
- article
- Volume
- 124
- Issue
- 2
- Pages
- 315-327
- Citations
- 1573
- Access
- Closed
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Cite This
Dennis Wolf,
Klaus Ley
(2019).
Immunity and Inflammation in Atherosclerosis.
Circulation Research
, 124
(2)
, 315-327.
https://doi.org/10.1161/circresaha.118.313591
Identifiers
- DOI
- 10.1161/circresaha.118.313591
- PMID
- 30653442
- PMCID
- PMC6342482