MGMT Gene Silencing and Benefit from Temozolomide in Glioblastoma

Abstract

Patients with glioblastoma containing a methylated MGMT promoter benefited from temozolomide, whereas those who did not have a methylated MGMT promoter did not have such a benefit.

Keywords

TemozolomideMedicineO-6-methylguanine-DNA methyltransferaseMethyltransferaseHazard ratioOncologyMethylationConfidence intervalDNA methylationInternal medicineRadiation therapyCancer researchDNA methyltransferaseBiologyGeneGeneticsGene expression

MeSH Terms

Antineoplastic AgentsAlkylatingBrain NeoplasmsChemotherapyAdjuvantDNA MethylationDacarbazineDisease-Free SurvivalGene SilencingGlioblastomaHumansO(6)-Methylguanine-DNA MethyltransferasePolymerase Chain ReactionPromoter RegionsGeneticRandomized Controlled Trials as TopicSurvival AnalysisTemozolomide

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Publication Info

Year: 2005
Type: article
Volume: 352
Issue: 10
Pages: 997-1003
Citations: 7001
Access: Closed

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APA Style

                            
                                
                                    Monika E. Hegi, 
                                
                                    Annie‐Claire Diserens, 
                                
                                    Thierry Gorlia
                                
                                et al.
                            
                            (2005). 
                            <i>MGMT</i> Gene Silencing and Benefit from Temozolomide in Glioblastoma. 
                            New England Journal of Medicine
                            , 352
                            (10)
                            , 997-1003.
                            https://doi.org/10.1056/nejmoa043331
                        

Identifiers

DOI: 10.1056/nejmoa043331
PMID: 15758010

Data Quality

Data completeness: 86%

<i>MGMT</i> Gene Silencing and Benefit from Temozolomide in Glioblastoma