Abstract
IL-6/sIL-6R directly induced RANKL expression in RA-FLS and it is essential for RANKL induction by TNF-alpha and IL-17. Moreover, RANKL induction by IL-6/sIL-6R is mediated by the janus kinase/STAT signalling pathway.
Keywords
RANKLMedicineTumor necrosis factor alphaMolecular biologyActivator (genetics)STAT proteinCancer researchPhosphorylationReceptorInternal medicineEndocrinologySTAT3BiologyCell biology
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Publication Info
- Year
- 2008
- Type
- article
- Volume
- 47
- Issue
- 11
- Pages
- 1635-1640
- Citations
- 346
- Access
- Closed
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Cite This
Misato Hashizume,
Naohiko Hayakawa,
Masahiko Mihara
(2008).
IL-6 trans-signalling directly induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF- and IL-17.
Lara D. Veeken
, 47
(11)
, 1635-1640.
https://doi.org/10.1093/rheumatology/ken363
Identifiers
- DOI
- 10.1093/rheumatology/ken363